Pub. Date : 2002 Jan
PMID : 11786475
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord. | Capsaicin | cannabinoid receptor 1 (brain) | Mus musculus |
| 2 | We have investigated a possible modulatory role for Type 1 Cannabinoid receptors (CB(1)) on the release of excitatory transmitter Substance P from the adult mouse spinal cord after stimulation of nociceptor terminals by capsaicin. | Capsaicin | cannabinoid receptor 1 (brain) | Mus musculus |
| 3 | Superfusion of CB(1) antagonist SR141716A (5 microM) increased evoked SP release with capsaicin (0.1 - 10 microM) and reversed the reducing effect of high dose capsaicin (100 microM). | Capsaicin | cannabinoid receptor 1 (brain) | Mus musculus |
| 4 | Superfusion of CB(1) antagonist SR141716A (5 microM) increased evoked SP release with capsaicin (0.1 - 10 microM) and reversed the reducing effect of high dose capsaicin (100 microM). | Capsaicin | cannabinoid receptor 1 (brain) | Mus musculus |
| 5 | Antagonism of CB(1) receptors in the spinal cord during capsaicin stimulation, is evidence of tonic CB(1) activity inhibiting the release of excitatory transmitters after activation of nociceptive neurones and is also indicative of endocannabinoid production during noxious stimulation. | Capsaicin | cannabinoid receptor 1 (brain) | Mus musculus |
| 6 | Antagonism of CB(1) receptors in the spinal cord during capsaicin stimulation, is evidence of tonic CB(1) activity inhibiting the release of excitatory transmitters after activation of nociceptive neurones and is also indicative of endocannabinoid production during noxious stimulation. | Capsaicin | cannabinoid receptor 1 (brain) | Mus musculus |