Title : Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats.

Pub. Date : 2002 Jan

PMID : 11786082






1 Functional Relationships(s)
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1 Treatment of diabetic Ren-2 rats with either valsartan (20 mg/kg/day) or perindopril (6 mg/kg/day) reduced apoptosis to control levels in association with supranormal levels of EGF mRNA (P < 0.01) and a reduction in TGF-beta1 gene expression (P < 0.05) to that of control rats. Valsartan transforming growth factor, beta 1 Rattus norvegicus