Title : Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells.

Pub. Date : 2002 Jan

PMID : 11786081






1 Functional Relationships(s)
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1 Since MnTBAP, a superoxide dismutase mimetic, had no effects on the amplification of mRNA levels, we suggest that H2O2 is the candidate reactive oxygen species (ROS) responsible for the potentiation of IL-1beta-triggered tPA and PAI-1 expression. Hydrogen Peroxide interleukin 1 beta Rattus norvegicus