Title : Anti-inflammatory activity of a novel selective cyclooxygenase-2 inhibitor, FR140423, on type II collagen-induced arthritis in Lewis rats.

Pub. Date : 2001 Dec

PMID : 11785783






1 Functional Relationships(s)
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1 These results suggest that FR140423 shows a potent anti-inflammatory effect mediated by inhibition of prostanoids produced by COX-2 in inflamed tissues immunized with type II collagen, with a greatly improved safety profile compared to indomethacin. Prostaglandins cytochrome c oxidase II, mitochondrial Rattus norvegicus