Pub. Date : 2001 Dec
PMID : 11775008
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our objective was to evaluate interleukin (IL)-1alpha-induced production of PGE2 and PGF2alpha in endometrial stromal cells (ESC) following treatment with ceramide analogues. | Dinoprost | interleukin 1 alpha | Homo sapiens |
| 2 | PGF2alpha production was further increased by treatment with the combination of IL-1alpha and C2-ceramide as compared with IL-1alpha treatment alone. | Dinoprost | interleukin 1 alpha | Homo sapiens |
| 3 | PGF2alpha production was further increased by treatment with the combination of IL-1alpha and C2-ceramide as compared with IL-1alpha treatment alone. | Dinoprost | interleukin 1 alpha | Homo sapiens |
| 4 | Both PGE2 and PGF2alpha production were significantly increased by treatment with IL-1alpha and C6-ceramide as compared with IL-1alpha treatment alone. | Dinoprost | interleukin 1 alpha | Homo sapiens |
| 5 | CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium. | Dinoprost | interleukin 1 alpha | Homo sapiens |
| 6 | CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium. | Dinoprost | interleukin 1 alpha | Homo sapiens |