Title : Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.

Pub. Date : 2001 Nov-Dec

PMID : 11774038






1 Functional Relationships(s)
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1 Since the region in Bcl-2 containing serine 70 and serine 87 represents a proline-rich loop that has been associated with autorepression of its antiapoptotic activity, the discovery of Pin1 interactions with phosphorylated Bcl-2 raises the possibility that Pin1 alters the conformation of Bcl-2 and thereby modulates its function in cells arrested with antimicrotubule drugs. Proline peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens