Title : Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes.

Pub. Date : 2001 Dec

PMID : 11770832






2 Functional Relationships(s)
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1 METHOD: CYP3A4 activities in human liver microsomes from 2 donors were determined using the oxidation of the dihydropyridine denitronifedipine, a specific CYP3A4 substrate, at a concentration of 50 microM (= KM). 1,4-dihydropyridine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 METHOD: CYP3A4 activities in human liver microsomes from 2 donors were determined using the oxidation of the dihydropyridine denitronifedipine, a specific CYP3A4 substrate, at a concentration of 50 microM (= KM). 1,4-dihydropyridine cytochrome P450 family 3 subfamily A member 4 Homo sapiens