Title : Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes.

Pub. Date : 2001 Dec

PMID : 11770832






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1 CONCLUSION: Comparing IC50 values with plasma concentrations present during antineoplastic therapy, the agents cyclophosphamide, ifosfamide, vinblastine, teniposide and docetaxel could possibly cause clinical drug interactions by inhibition of CYP3A4. Cyclophosphamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens