Title : Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1.

Pub. Date : 2002 Mar 22

PMID : 11756433






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 These data suggest that COX-2 inhibits mesangial cell proliferation by a novel mechanism that is independent of prostaglandin synthesis, but involves p53, p21(cip-1), and p27(kip-1). Prostaglandins prostaglandin-endoperoxide synthase 2 Mus musculus