Title : Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes.

Pub. Date : 2002 Jan

PMID : 11756226






4 Functional Relationships(s)
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1 The tumor promoters phorbol 12-myristate 13-acetate (PMA) and chenodeoxycholic acid (CD) induced COX-2 protein expression in transformed, but not non-transformed cells. Tetradecanoylphorbol Acetate mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The tumor promoters phorbol 12-myristate 13-acetate (PMA) and chenodeoxycholic acid (CD) induced COX-2 protein expression in transformed, but not non-transformed cells. Tetradecanoylphorbol Acetate mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 PMA-induced COX-2 expression in both transformed and CYP2E1-expressing cells resulted from an induction in COX-2 mRNA, and was dependent on extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Tetradecanoylphorbol Acetate mitochondrially encoded cytochrome c oxidase II Homo sapiens
4 PMA-induced COX-2 expression in both transformed and CYP2E1-expressing cells resulted from an induction in COX-2 mRNA, and was dependent on extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Tetradecanoylphorbol Acetate mitochondrially encoded cytochrome c oxidase II Homo sapiens