Title : Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors.

Pub. Date : 2002 Jan 3

PMID : 11754588






1 Functional Relationships(s)
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1 A series of trans-stilbene derivatives containing a 3,5-dimethoxyphenyl moiety were prepared through a new efficient solution phase synthetic pathway, and their inhibitory activities were evaluated on human cytochrome P450s (CYP) 1A1, 1A2, and 1B1 to find a potent and selective CYP1B1 inhibitor. 3,5-dimethoxyphenyl cytochrome P450 family 1 subfamily A member 1 Homo sapiens