Pub. Date : 2001
PMID : 11752888
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Among all the drugs tested, only propranolol increased plasma TNF-alpha. | Propranolol | tumor necrosis factor | Rattus norvegicus |
| 2 | On the contrary, propranolol, a beta-receptor blocker, induced a highly significant 3-fold increase in plasma TNF-alpha concentrations at 30 min and augmented the response to LPS 2-fold after endotoxin injection. | Propranolol | tumor necrosis factor | Rattus norvegicus |
| 3 | The fact that isoproterenol decreased the LPS-induced TNF-alpha release, whereas propranolol augmented basal and LPS-induced release suggests that the sympathetic nervous system inhibits basal and LPS-stimulated TNF-alpha release via beta-adrenergic receptors. | Propranolol | tumor necrosis factor | Rattus norvegicus |