Pub. Date : 2001 Dec
PMID : 11751448
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin, a polyphenol derived from Curcuma spp., has shown wide-ranging chemopreventive activity in preclinical carcinogenic models, in which it inhibits cyclooxygenase (COX)-2 at the transcriptional level. | Curcumin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | When 1 microM curcumin was added in vitro to blood from healthy volunteers, LPS-induced COX-2 protein levels and concomitant PGE(2) production were reduced by 24% and 41%, respectively (P < 0.05 by ANOVA). | Curcumin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |