Title : Activation of p42/44 mitogen-activated protein kinase pathway in long-term potentiation induced by nicotine in hippocampal CA1 region in rats.

Pub. Date : 2001 Aug

PMID : 11749838






3 Functional Relationships(s)
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1 Activation of p42/44 mitogen-activated protein kinase pathway in long-term potentiation induced by nicotine in hippocampal CA1 region in rats. Nicotine carbonic anhydrase 1 Rattus norvegicus
2 AIM: To investigate the relationship between activation of p42/44 mitogen-activated protein kinase (MAPK) pathway and hippocampal long term potentiation (LTP) induced by nicotine in area CA 1. Nicotine carbonic anhydrase 1 Rattus norvegicus
3 RESULTS: PD98059 concentration-dependently (25 micromol/L, 50 micromol/L) attenuated the induction of LTP induced by nicotine 10 micromol/L; both p42 and p44 MAPK were activated with their total protein expression increasing in CA1 subregion in response to LTP induced by nicotine. Nicotine carbonic anhydrase 1 Rattus norvegicus