Title : Elongated multiple electronic cascade and cyclization spacer systems in activatible anticancer prodrugs for enhanced drug release.

Pub. Date : 2001 Dec 28

PMID : 11749612






1 Functional Relationships(s)
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1 Prodrugs in which the novel spacer systems were incorporated between a specific tripeptide specifier and the parent drug doxorubicin or paclitaxel proved to be significantly faster activated by plasmin in comparison with prodrugs containing conventional spacer systems. tripeptide K-26 plasminogen Homo sapiens