Pub. Date : 2001 Dec 20
PMID : 11741479
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By constructing diarylurea informer libraries based on the structural requirements of Cdk inhibitors in the ATP binding pocket of the Cdk4 model, we were able to identify a potent Cdk4 inhibitor N-(9-oxo-9H-fluoren-4-yl)-N"-pyridin-2-ylurea 15 (IC(50) = 0.10 microM), together with preliminary SAR. | Adenosine Triphosphate | sarcosine dehydrogenase | Homo sapiens |