Pub. Date : 2001 Dec 21
PMID : 11741297
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |