Title : DNA damage by the enediyne C-1027 results in the inhibition of DNA replication by loss of replication protein A function and activation of DNA-dependent protein kinase.

Pub. Date : 2001 Dec 4

PMID : 11724580






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The deficiency in RPA in extracts from cells treated with low levels of C-1027 can be fully complemented by the addition of exogenous RPA, and may be due to a C-1027-induced decrease in the extractability of RPA. Carbon replication protein A1 Homo sapiens
2 The deficiency in RPA in extracts from cells treated with low levels of C-1027 can be fully complemented by the addition of exogenous RPA, and may be due to a C-1027-induced decrease in the extractability of RPA. Carbon replication protein A1 Homo sapiens
3 The deficiency in RPA in extracts from cells treated with low levels of C-1027 can be fully complemented by the addition of exogenous RPA, and may be due to a C-1027-induced decrease in the extractability of RPA. Carbon replication protein A1 Homo sapiens