Pub. Date : 2001 Nov
PMID : 11719734
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low sodium and furosemide-induced stimulation of the renin system in man is mediated by cyclooxygenase 2. | Furosemide | renin | Homo sapiens |
| 2 | Plasma renin activity increased 2 to 3 times over baseline with a low-sodium diet and 5 times over baseline 30 minutes after intravenous furosemide; it was still elevated nearly 5 times on day 9. | Furosemide | renin | Homo sapiens |
| 3 | We have concluded that low-sodium and furosemide-stimulated renin and aldosterone secretion is completely blocked in healthy volunteers during COX-2 inhibition with rofecoxib, suggesting that intact COX-2 is of major importance for stimulation of the renin system under these conditions in man. | Furosemide | renin | Homo sapiens |
| 4 | We have concluded that low-sodium and furosemide-stimulated renin and aldosterone secretion is completely blocked in healthy volunteers during COX-2 inhibition with rofecoxib, suggesting that intact COX-2 is of major importance for stimulation of the renin system under these conditions in man. | Furosemide | renin | Homo sapiens |