Title : Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade.

Pub. Date : 2001 Nov 15

PMID : 11719466






1 Functional Relationships(s)
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1 Taken together, this study shows that a PKC-epsilon-Raf-1-MEK-ERK-AP1 signaling cascade acts on a 12-O-tetradecanoylphorbol-13-acetate response element-like element to mediate hypoxia-induced GRP78 expression in human gastric cancer cells. Tetradecanoylphorbol Acetate Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens