Title : Differential susceptibility of cultured cell lines to aggregate formation and cell death produced by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.

Pub. Date : 2001 Oct-Nov 1

PMID : 11719271






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Ataxin-3, a protein coded by the Machado-Joseph disease gene, possesses a polyglutamine stretch whose expansion is known to produce neuronal intranuclear inclusion and neurodegeneration. polyglutamine ataxin 3 Homo sapiens
2 Our data indicates that susceptibility to cell death produced by mutant truncated ataxin-3 differs significantly among different cell lines and provides useful information when using a cultured cell line as an in vitro cellular model of polyglutamine disease. polyglutamine ataxin 3 Homo sapiens