Title : Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.

Pub. Date : 2001 Dec 10

PMID : 11716543






2 Functional Relationships(s)
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1 We found that curcumin caused cell death in eight melanoma cell lines, four with wild-type and four with mutant p53. Curcumin tumor protein p53 Homo sapiens
2 Since melanoma cells with mutant p53 are strongly resistant to conventional chemotherapy, curcumin may overcome the chemoresistance of these cells and provide potential new avenues for treatment. Curcumin tumor protein p53 Homo sapiens