Title : Wine phenolic antioxidants inhibit AP-1 transcriptional activity.

Pub. Date : 2001 Nov

PMID : 11714372






1 Functional Relationships(s)
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1 The aim of this study was to evaluate the modulation of AP-1 activity by the phenolic acids (gallic, caffeic, protocatechic, paracoumaric, sinapic, and ferulic acids) that are present in wine and to compare their modulating pathways to those of lipophilic or hydrophilic "chain-breaking" antioxidants (such as DL-alpha-tocopherol or trolox) vitamin C, nitric oxide, and reduced glutathione. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens