Pub. Date : 2001 Nov 23
PMID : 11711216
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The involvement of nitric oxide (NO) in cerebral blood flow (CBF) stimulation by acetazolamide was studied in anaesthetised, mechanically ventilated Wistar rats. | Acetazolamide | CCAAT/enhancer binding protein zeta | Rattus norvegicus |
| 2 | Acetazolamide induced a long-lasting significant rCBF-increase. | Acetazolamide | CCAAT/enhancer binding protein zeta | Rattus norvegicus |
| 3 | Application of NG-Nitro-L-arginine (L-NNA), an inhibitor of all NO synthetases (NOS), prevented CBF stimulation by acetazolamide. | Acetazolamide | CCAAT/enhancer binding protein zeta | Rattus norvegicus |
| 4 | Additional acetazolamide injection then again caused a significant increase of rCBF in spite of NOS-inhibition. | Acetazolamide | CCAAT/enhancer binding protein zeta | Rattus norvegicus |
| 5 | We thus conclude that NO is involved in acetazolamide-induced CBF stimulation. | Acetazolamide | CCAAT/enhancer binding protein zeta | Rattus norvegicus |
| 6 | These data suggest that NO acts rather as a modulator than as a mediator of the acetazolamide-induced CBF response. | Acetazolamide | CCAAT/enhancer binding protein zeta | Rattus norvegicus |