Title : Inhibition of COX-2 counteracts the effects of diuretics in rats.

Pub. Date : 2001 Nov

PMID : 11703585






2 Functional Relationships(s)
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1 RESULTS: Induction of COX-2 mRNA expression due to furosemide was paralleled by increased renal excretion of prostanoids. Furosemide cytochrome c oxidase II, mitochondrial Rattus norvegicus
2 Moreover, the COX-2 inhibitor rofecoxib dose-dependently attenuated diuresis and saluresis, as well as the stimulation of the renin system induced by furosemide. Furosemide cytochrome c oxidase II, mitochondrial Rattus norvegicus