Title : Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.

Pub. Date : 2001 Nov

PMID : 11701475






1 Functional Relationships(s)
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1 Ciprofibrate and the PPARalpha agonist Wy14,643 decreased bile acid synthesis in cultured rat hepatocytes and suppressed cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase activities, paralleled by a similar reduction of the respective mRNAs. ciprofibrate cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus