Title : Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.

Pub. Date : 2001 Nov

PMID : 11696579






2 Functional Relationships(s)
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1 Both the inhibition of eNOS and the changes in its post-translational modifications were reversed by antisense inhibition of glutamine:fructose-6-phosphate amidotransferase, the rate-limiting enzyme of the hexosamine pathway, or by blocking mitochondrial superoxide overproduction with uncoupling protein-1 (UCP-1) or manganese superoxide dismutase (MnSOD). Hexosamines superoxide dismutase 2 Homo sapiens
2 Both the inhibition of eNOS and the changes in its post-translational modifications were reversed by antisense inhibition of glutamine:fructose-6-phosphate amidotransferase, the rate-limiting enzyme of the hexosamine pathway, or by blocking mitochondrial superoxide overproduction with uncoupling protein-1 (UCP-1) or manganese superoxide dismutase (MnSOD). Hexosamines superoxide dismutase 2 Homo sapiens