Title : Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription.

Pub. Date : 2001 Apr

PMID : 11689104






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To complement the gene promoter studies, we determined the effects of a mixture of shikonins on phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 in transformed human mammary epithelial cells. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
2 To complement the gene promoter studies, we determined the effects of a mixture of shikonins on phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 in transformed human mammary epithelial cells. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
3 In transient transfections, PMA caused a severalfold increase in COX-2 promoter activity, an effect that was suppressed by shikonins. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens