Pub. Date : 2001 Nov
PMID : 11685249
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched tyrosine phosphatase PEP in hematopoietic cells. | Proline | prolyl endopeptidase | Homo sapiens |
| 2 | The solution structure of the Csk-SH3 domain in complex with a 25-residue peptide from the Pro/Glu/Ser/Thr-rich (PEST) domain of PEP reveals the basis for this specific peptide recognition motif involving an SH3 domain. | Proline | prolyl endopeptidase | Homo sapiens |
| 3 | Three residues, Ala 40, Thr 42 and Lys 43, in the SH3 domain of Csk specifically recognize two hydrophobic residues, Ile 625 and Val 626, in the proline-rich sequence of the PEST domain of PEP. | Proline | prolyl endopeptidase | Homo sapiens |
| 4 | These two residues are C-terminal to the conventional proline-rich SH3 domain recognition sequence of PEP. | Proline | prolyl endopeptidase | Homo sapiens |