Pub. Date : 2001
PMID : 11684819
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21waf1/cip1. | Pioglitazone | TNF superfamily member 10 | Homo sapiens |
| 2 | Additionally, pioglitazone significantly enhanced carcinoid cell death induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). | Pioglitazone | TNF superfamily member 10 | Homo sapiens |
| 3 | The enhancement of TRAIL-induced apoptosis was associated with an upregulation of cyclin-dependent kinase inhibitor p21waf1/cip1 in pioglitazone-treated carcinoid cells. | Pioglitazone | TNF superfamily member 10 | Homo sapiens |
| 4 | CONCLUSIONS: These results suggest that pioglitazone inhibits cell growth and sensitizes cells to TRAIL-induced apoptosis by induction of p21waf1/cip1. | Pioglitazone | TNF superfamily member 10 | Homo sapiens |