Pub. Date : 2001 Dec 28
PMID : 11679579
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | R67 is a Type II dihydrofolate reductase (DHFR) that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate by facilitating the addition of a proton to N5 of DHF and the transfer of a hydride ion from NADPH to C6. | dihydrofolate | dihydrofolate reductase | Escherichia coli |
| 2 | R67 is a Type II dihydrofolate reductase (DHFR) that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate by facilitating the addition of a proton to N5 of DHF and the transfer of a hydride ion from NADPH to C6. | dihydrofolate | dihydrofolate reductase | Escherichia coli |
| 3 | Here, Raman difference measurements, conducted on the ternary complex of R67.NADP(+).DHF believed to be an accurate mimic of the productive DHFR.NADPH.DHF complex, show that the pK(a) of N5 in the complex is less than 4. | dihydrofolate | dihydrofolate reductase | Escherichia coli |