Title : Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349.

Pub. Date : 2002 Jan 4

PMID : 11677234






1 Functional Relationships(s)
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1 Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15. Arachidonic Acid mitochondrially encoded cytochrome c oxidase I Homo sapiens