Title : A novel prostaglandin E receptor subtype agonist, 0N0-4819, attenuates acute experimental liver injury in rats.

Pub. Date : 2001 Nov

PMID : 11673110






2 Functional Relationships(s)
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1 Although serum levels of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and interleukin-8 (IL-8) were markedly elevated after GalN/LPS administration, ONO-4819 significantly inhibited the elevation of those of TNF-alpha and IFN-gamma but not that of IL-8. Galactosamine tumor necrosis factor Rattus norvegicus
2 Although serum levels of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and interleukin-8 (IL-8) were markedly elevated after GalN/LPS administration, ONO-4819 significantly inhibited the elevation of those of TNF-alpha and IFN-gamma but not that of IL-8. Galactosamine tumor necrosis factor Rattus norvegicus