Title : cAMP inhibits IP(3)-dependent Ca(2+) release by preferential activation of cGMP-primed PKG.

Pub. Date : 2001 Nov

PMID : 11668033






3 Functional Relationships(s)
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Protein Name
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1 cAMP inhibits IP(3)-dependent Ca(2+) release by preferential activation of cGMP-primed PKG. Cyclic AMP protein kinase cGMP-dependent 1 Homo sapiens
2 In permeabilized muscle cells, exogenous cAMP and cGMP inhibited inositol 1,4,5-trisphosphate (IP(3))-induced Ca(2+) release and muscle contraction via PKA and PKG, respectively. Cyclic AMP protein kinase cGMP-dependent 1 Homo sapiens
3 A combination of cAMP and cGMP caused synergistic inhibition that was exclusively mediated by PKG and attenuated by PKA. Cyclic AMP protein kinase cGMP-dependent 1 Homo sapiens