Title : New anti-inflammatory N-pyridinyl(alkyl)phthalimides acting as tumour necrosis factor-alpha production inhibitors.

Pub. Date : 2001 Jul-Aug

PMID : 11600233






1 Functional Relationships(s)
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1 Variation of the substituents linked to the homocycle of their phthalimide scaffold indicated that high (TNFalpha production) inhibitory potency could be achieved, notably by 5-fluoro, 4- or 5-nitro, 5-amino and especially tetrafluoro substitution. phthalimide tumor necrosis factor Rattus norvegicus