Title : Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes.

Pub. Date : 2001 Dec 28

PMID : 11598110






1 Functional Relationships(s)
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1 DPI completely inhibited the activation of phosphatidylinositol (PI) 3"-kinase activity by insulin and reduced the insulin-induced activation of the serine kinase Akt by up to 49%; these activities were restored when H(2)O(2) was added back to cells that had been pretreated with DPI. diphenyleneiodonium AKT serine/threonine kinase 1 Homo sapiens