Title : Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes.

Pub. Date : 2001 Dec 28

PMID : 11598110






2 Functional Relationships(s)
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1 Interestingly, the H(2)O(2)-induced activation of Akt was entirely mediated by upstream stimulation of PI 3"-kinase activity, since treatment of 3T3-L1 adipocytes with the PI 3"-kinase inhibitors wortmannin or LY294002 completely blocked the subsequent activation of Akt by exogenous H(2)O(2). Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
2 Interestingly, the H(2)O(2)-induced activation of Akt was entirely mediated by upstream stimulation of PI 3"-kinase activity, since treatment of 3T3-L1 adipocytes with the PI 3"-kinase inhibitors wortmannin or LY294002 completely blocked the subsequent activation of Akt by exogenous H(2)O(2). Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens