Pub. Date : 2001 Oct 15
PMID : 11597580
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. | Resveratrol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | Resveratrol decreases basal and induced CYP1A1 mRNA/protein levels in both in vitro and in vivo models, and some studies suggest that resveratrol acts as an aryl hydrocarbon receptor (AhR) antagonist. | Resveratrol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Treatment of T47D or MCF-7 cells with 10 microM resveratrol inhibited induction of CYP1A1 mRNA and CYP1A1-dependent activity after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), as previously reported. | Resveratrol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | Treatment of T47D or MCF-7 cells with 10 microM resveratrol inhibited induction of CYP1A1 mRNA and CYP1A1-dependent activity after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), as previously reported. | Resveratrol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | Actinomycin D chase experiments in T47D cells showed that resveratrol and dehydroepiandrosterone both increased the rate of CYP1A1 mRNA degradation, whereas resveratrol did not affect CYP1A1-dependent activity in cells pretreated with TCDD for 18 hr. | Resveratrol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 6 | These data suggest that resveratrol inhibits CYP1A1 via an AhR-independent post-transcriptional pathway. | Resveratrol | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |