Pub. Date : 2001 Dec 7
PMID : 11595732
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid-mediated growth arrest requires ubiquitylation and degradation of the F-box protein Skp2. | Tretinoin | S-phase kinase associated protein 2 | Homo sapiens |
| 2 | Furthermore, we demonstrate that ATRA promotes the ubiquitylation of Skp2, an F-box protein that targets p27 for degradation. | Tretinoin | S-phase kinase associated protein 2 | Homo sapiens |
| 3 | We found that the mechanism of ATRA-induced ubiquitylation of cyclin D1 and Skp2 is independent of CUL-1 expression and that ATRA can rescue cyclin D1 degradation in the uterine cell line SK-UT-1, where D-type cyclins are stabilized due to a specific defect in proteolysis. | Tretinoin | S-phase kinase associated protein 2 | Homo sapiens |
| 4 | These data suggest that ATRA induces a novel pathway of ubiquitylation and that the degradation of the F-box protein Skp2 is the mechanism underlying p27 accumulation and cyclin E-cdk2 inactivation following ATRA treatment. | Tretinoin | S-phase kinase associated protein 2 | Homo sapiens |
| 5 | These data suggest that ATRA induces a novel pathway of ubiquitylation and that the degradation of the F-box protein Skp2 is the mechanism underlying p27 accumulation and cyclin E-cdk2 inactivation following ATRA treatment. | Tretinoin | S-phase kinase associated protein 2 | Homo sapiens |