Title : IL-1beta down-regulates tissue-type plasminogen activator by up-regulating low-density lipoprotein receptor-related protein in AML 12 cells.

Pub. Date : 2001 Oct 19

PMID : 11594749






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Interleukin-1 (IL-1) regulation of tPA in hepatocytes was studied in mouse hepatocyte line AML12. Tetradecanoylphorbol Acetate interleukin 1 complex Mus musculus
2 Interleukin-1 (IL-1) regulation of tPA in hepatocytes was studied in mouse hepatocyte line AML12. Tetradecanoylphorbol Acetate interleukin 1 complex Mus musculus
3 IL-1 induced transient accumulation of tPA mRNA as high as threefold by 2 h after the start of treatment. Tetradecanoylphorbol Acetate interleukin 1 complex Mus musculus
4 These results revealed that low-density lipoprotein receptor-related protein (LRP), which is known to be a receptor for tPA and to be blocked by RAP, was up-regulated by IL-1. Tetradecanoylphorbol Acetate interleukin 1 complex Mus musculus