Title : Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences.

Pub. Date : 2001 Oct 15

PMID : 11594730






2 Functional Relationships(s)
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1 Experiments in vitro demonstrate that peroxynitrite treatment of recombinant wild-type p53 at physiological concentrations results in formation of higher molecular weight aggregates, tyrosine nitration, and loss of specific DNA binding. Tyrosine tumor protein p53 Homo sapiens
2 Peroxynitrite treatment of human glioma cell lysates similarly resulted in selective tyrosine nitration of p53 and was also associated with loss of p53 DNA binding ability. Tyrosine tumor protein p53 Homo sapiens