Title : CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO.

Pub. Date : 2001 Oct 9

PMID : 11593028






1 Functional Relationships(s)
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1 Our results therefore indicate a mechanism whereby CD26 engagement promotes aggregation of lipid rafts and facilitates colocalization of CD45 to T cell receptor signaling molecules p56(Lck), ZAP-70, and TCRzeta, thereby enhancing protein tyrosine phosphorylation of various signaling molecules and subsequent interleukin-2 production. Tyrosine dipeptidyl peptidase 4 Homo sapiens