Title : DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair.

Pub. Date : 2001 Oct 9

PMID : 11593023






1 Functional Relationships(s)
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Protein Name
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1 The LIG4(-/-) cells showed a marked sensitivity to X-rays, bleomycin, and VP-16 and were more x-ray-sensitive in G(1) than late S or G(2)/M, suggesting a critical role of Lig4 in DSB repair by NHEJ. Etoposide ligase IV, DNA, ATP-dependent Mus musculus