Title : Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents.

Pub. Date : 2001 Oct

PMID : 11592233






1 Functional Relationships(s)
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1 JNK activity was decreased by 1.8-fold, as well as the expression of its downstream target c-jun (1.9-fold), when tumor cells were exposed to cisplatin in the presence of nicotine. Nicotine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens