Title : Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells.

Pub. Date : 2001 Dec 7

PMID : 11590175






3 Functional Relationships(s)
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1 We found that the inhibition of ODC by alpha-difluoromethylornithine (DFMO) resulted in a approximately 50% decrease in intracellular putrescine levels within 1 h. NF-kappa B is activated by DFMO through the degradation of the inhibitory protein I kappa B alpha that sequesters NF-kappa B in the cytoplasm. Eflornithine ornithine decarboxylase 1 Rattus norvegicus
2 We found that the inhibition of ODC by alpha-difluoromethylornithine (DFMO) resulted in a approximately 50% decrease in intracellular putrescine levels within 1 h. NF-kappa B is activated by DFMO through the degradation of the inhibitory protein I kappa B alpha that sequesters NF-kappa B in the cytoplasm. Eflornithine ornithine decarboxylase 1 Rattus norvegicus
3 We found that the inhibition of ODC by alpha-difluoromethylornithine (DFMO) resulted in a approximately 50% decrease in intracellular putrescine levels within 1 h. NF-kappa B is activated by DFMO through the degradation of the inhibitory protein I kappa B alpha that sequesters NF-kappa B in the cytoplasm. Eflornithine ornithine decarboxylase 1 Rattus norvegicus