Title : Plasmin cleaves Abeta42 in vitro and prevents its aggregation into beta-pleated sheet structures.

Pub. Date : 2001 Sep 17

PMID : 11588612






1 Functional Relationships(s)
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1 We have used RP-HPLC and thioflavin T fluorescence to demonstrate that Abeta42 is rapidly cleaved by the protease plasmin and that cleavage prevented the aggregation of Abeta42, and its cleavage products, into beta-pleated sheet structures. thioflavin T plasminogen Homo sapiens