Title : Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.

Pub. Date : 2001 Oct 1

PMID : 11585742






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 p53 codons containing methylated CpG sequences are preferential targets for formation of adducts by (+/-) anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). 8alpha-dihydroxy-9alpha tumor protein p53 Homo sapiens