Title : Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.

Pub. Date : 2001 Oct 11

PMID : 11585438






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Piperazine-based CCR5 antagonists as HIV-1 inhibitors. Piperazine C-C motif chemokine receptor 5 Homo sapiens
2 Further optimization for pharmacokinetic properties afforded Sch-350634 (1), a prototypical piperazine-based CCR5 antagonist, which is a potent inhibitor of HIV-1 entry and replication in PBMCs. Piperazine C-C motif chemokine receptor 5 Homo sapiens