Title : Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.

Pub. Date : 2001 Nov 23

PMID : 11583985






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Unexpectedly, the APP-CTFgamma derivative is generated by processing between Leu-645 and Val-646 (of APP(695)), several amino acids carboxyl-terminal to the scissile bonds for production of amyloid beta protein peptides. Leucine amyloid beta precursor protein Homo sapiens