Title : Bacterial lipopolysaccharides and innate immunity.

Pub. Date : 2001

PMID : 11581570






1 Functional Relationships(s)
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1 According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18. Lipid A CD14 molecule Homo sapiens